Large ulceration of the oropharynx induced by methotrexate-associated lymphoproliferative disorders.
نویسندگان
چکیده
We present a case of a 67-year-old Japanese man with a serious oropharyngeal ulceration that at first seemed to be destructive malignant lymphoma or oropharyngeal carcinoma. We suspected methotrexate (MTX)-associated lymphoproliferative disorder (LPD) induced by MTX treatment for rheumatoid arthritis (RA). About 3 weeks after simple discontinuation of MTX, complete regression of the disease was observed, confirming our diagnosis.
منابع مشابه
Atypical methotrexate ulcerative stomatitis with features of lymphoproliferative like disorder: Report of a rare ciprofloxacin-induced case and review of the literature
Methotrexate (MTX) is an established immunomodulating agent used in low doses (LDMTX) to treat several autoimmune diseases. Ulcerative stomatitis (US) may be observed as a long-term LDMTX adverse effect showing a wide histopathologic spectrum. A 73-year old female presented with painful oral ulcers of 5 days duration. The patient had been under treatment for rheumatoid arthritis with LDMTX, whi...
متن کامل[Methotrexate-associated lymphoproliferative disorder presenting as oral ulcers in a patient with rheumatoid arthritis].
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Picture 1. Oral tumor and chest computed tomography of the patient. (A). Oral finding on ad mission shows upper gingival tumor with bleeding and ulceration. (B). Computed tomography (CT) scan of the chest revealed multiple tumors in bilateral lung bases. (C). Oral tumor was re duced in size immediately 14 days after methotrexate withdrawal. (D). Chest CT on day 41 after withdrawal of MTX shows ...
متن کاملSuccessful treatment of immunodeficiency-associated EBV-negative lymphoproliferative disorders in rheumatoid arthritis by methotrexate withdrawal and prevention of its relapse by rituximab administration.
Immunodeficiency-associated lymphoproliferative disorders (LPD) in rheumatoid arthritis are a rare, aggressive, and life-threatening clinical entity. We describe a 60-year-old man who had rheumatoid arthritis that was treated with methotrexate. Eight months after the treatment, the case was diagnosed as Epstein-Barr virus-negative LPD (diffuse large B-cell lymphoma) with abdominal bulky mass an...
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ورودعنوان ژورنال:
- Acta medica Okayama
دوره 67 4 شماره
صفحات -
تاریخ انتشار 2013